Successful human reproduction requires normal development of oocyte, sperm and early embryos. The abnormality and dysfunction in any of these processes will result in infertility. We mainly focus on genetic mechanism of abnormal development of human oocytes and early embryos, including oocyte maturation arrest, failure to be fertilization, early embryonic arrest, et al. By using methodology of medical genetics as well as functional genomics, we seek to identify disease-causing mutant genes and figure out corresponding molecular mechanism. In our research, clinical samples, mouse model, even monkey model are commonly utilized.
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